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So, with little previous research in this area we were keen to understand why this was the case and to find out what impact there was on the safety of patients. She added: We believe there is an opportunity for healthcare professionals to encourage patients to come to them for advice as our research showed that 72% are finding information around medication from online, closed support groups

Most clinical trials employed gradual dose titration protocols specifically to minimize gastrointestinal side effects, with discontinuation rates due to GI adverse events ranging from 47% in the STEP trials